Endocrine Abstracts

Background and Objectives: Polycystic ovary syndrome (PCOS) is a common female reproductive endocrine disorder with a prevalence of 15-20%. Although a majority of patients diagnosed with PCOS are overweight/obese, minority can present with normal body mass index of ≤25 kg/M2 which complicate the effective diagnosis and management. We have studied the socio-demographic and clinical characteristics of lean PCOS patients in comparison to obese PCOS patients atten...

Background and Objectives: Polycystic ovary syndrome (PCOS) is a common endocrine disorder with heterogeneous eatiology. It is characterized by irregular menses and or oligo/anovulation, hyper-androgenism, and polycystic ovaries. The prevalence and diagnosis of PCOS changes depending on which clinical criteria are utilized to confirm the diagnosis. The prevalence can be high as 15%–20% when the Rotterdam criteria are used. However, there is significant inter-individual va...

Background and Objectives: Non-alcoholic fatty liver disease (NAFLD) is the presence of hepatic steatosis in the absence of other causes for secondary hepatic fat accumulation. The incidence and the prevalence of the NAFLD has risen exponentially in the recent past especially in the patients with diabetes. We have studied the prevalence of NAFLD in patients with diabetes attending the diabetes clinic based on the biochemical and ultrasonic criteria, the risk factors for diseas...

Background and Objectives: The prevalence of pre-diabetes and diabetes has risen exponentially in the recent past. Though the symptomatic patients frequently undergo testing for the diagnosis of the disease, asymptomatic individuals are not routinely subjected to diagnostic testing. Thus, data on asymptomatic people are still lacking. We have studied the prevalence of pre-diabetes and diabetes in asymptomatic subjects attending the Endocrinology clinic in a tertiary care insti...

Background: Diabetic neuropathy, especially distal symmetric polyneuropathy (DSPN), is a common but under-recognized problem among people living with diabetes, particularly in developing countries. Aims: We aimed to describe the clinical characteristics, associated factors, treatment practices, outcomes and impact of DSPN among Sri Lankan adults living with diabetes.Methods: A cross sectional study was conducted at the Diabetes Clinic of National Hospita...

Introduction: The relation between polycystic ovary syndrome (PCOS) and cardiovascular disease (CVD) remains unclear. The aim of the study was to systematically review the relevant trials that have studied CVD risk factors in woman with PCOS (CRP, Hcy, TNF-α, PAI-1, Lp(a), AGEs, VEGF, IL6, ADMA and fibrinogen) and to meta-analyze the best evidence available.Patients and methods: Search was conducted in the MEDLINE, EMBASE and CENTRAL d (last update ...

Introduction: Non-syndromic autosomal recessively inherited non-goitrous congenital hypothyroidism (CHNG) can be caused by mutations in TSHR, PAX8, TSHB, and NKX2-5. We aimed to investigate mutational frequencies of these genes and genotype/phenotype correlations in consanguineous families with CHNG.Design: Since consanguinity in individuals with a presumptive genetic condition is often an indicator of an autosomal recessive inherita...